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My thoughts

Beware of supplements

6/13/2022

 
Updated 6/5/25

Do you know?
  • Not intended to treat, lessen, prevent, or cure disease
  • Supplements aren’t regulated by the FDA.
  • Comes with risks related to contamination with toxins, interactions with conventional medicines, unwanted side effects, and health problems
  • There isn't high quality evidence regarding diet supplements.
  • Products labeled natural aren’t necessarily safer.
  • Can create dependence on the agent - producing a sense of helplessness and reminding the user of the pain

​Editor’s note: This article was written based on my experience and what I have researched about the topic.  Everyone is different. The decision to use supplements should be a decision between you and your doctor.

Many people use supplements as part of their pain treatment plan, often as substitutes for prescribed medication that aren't often effective or well, tolerated.

However, supplements come with risk, including contamination with toxins, health problems, unwanted side effects, and interactions with conventional medicines. 

Unlike prescription or over-the-counter drugs, which must be approved by the Federal Drug Agency (FDA) before they can be marketed, the FDA doesn’t review supplements for safety and effectiveness before they are sold.
 
We don’t know where the products are made, how they are made, what is in them, and if the dosage is appropriate.
 
Safety is left up to the manufacturers and distributors of the supplements.  

Taking pills can reinforce the pain

besides the safety concern, each time you take a pill or supplement, you're reminding yourself you're in pain - reinforcing the neural pathways and keeping you in the pain cycle.

My experience
As part of the multi-day Mayo Clinic fibromyalgia program I attended in 2016, I met with a pharmacist to review the long list of prescription medicines, over-the-counter medicines, and supplements I was taking at the time. My medicine cabinet looked like a GNC store.
 
I was instructed to bring the actual bottles with me to the appointment, so I packed the bottles into a gym bag (yes, I was taking a lot of medicines and supplements) and went to see her.
 
I was surprised as she read each bottle, making comments and recommendations about each pill – including product quality, labeling issues, ingredient safety, and dosing.  
 
When the appointment ended, my medicine and supplement list was much shorter with her recommending stopping most of the supplements and my gym bag much lighter – throwing away the pills was going to stop taking. I kept only one supplement - Vitamin D, which I no longer use.

Bottom line
You assume all risk when using supplements. While some may be helpful, many aren’t and some may even be harmful. And they can become a unhelpful pain behavior - reminding you of the pain.

Review any supplements with your medical team to help you make an educated decision.
 
Learn more
  • American Roulette — Contaminated Dietary Supplements
  • Supplements: They’re Not As Safe As You Might Think
  • The role of diet and non-pharmacologic supplements in the treatment of chronic neuropathic pain: A systematic review
  • Harmful effects of supplements can send you to the emergency department
  • Natural supplements can be dangerously contaminated, or not even have the specified ingredients
  • Hundreds of Dietary Supplements Are Tainted with Prescription Drugs
  • Herbal Medicine for Pain Management: Efficacy and Drug Interactions
  • Dr. Pieter Cohen Explains Dietary Supplements and Regulations
  • Cannabidiol (CBD) Products for Pain: Ineffective, Expensive, and With Potential Harms
  • What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD
  • Central Sensitization Syndrome (CSS) - Dr. Christopher Sletten (22;19)
  • Medical cannabis for chronic pain? (my blog post)
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